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COPD and cancer mortality: the influence of statins

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Chronic obstructive pulmonary disease (COPD) is a progressive disease resulting to severity leading to difficulty in breathing, wheezing, and shortness of breath. The presence of certain diseases of the lungs, especially chronic obstructive pulmonary disease (COPD) is associated with an increased risk for the advancement of lung cancer. Statins are beneficial in preventing cardiovascular diseases; researchers have also found that statins work against critical cellular functions that may help control tumor initiation, tumor growth, and metastasis. A study was conducted to investigate the bridge between COPD and total cancer mortality rate and also to determine the use of statins associated with cancer risk.

3371 patients with peripheral arterial disease who underwent vascular surgery during 1990 and 2006 were included in the study. 39% suffered from COPD and the primary endpoint was assessed depending on the mortality rate of cancer over a follow-up of 5 years. The results showed that COPD was associated with an increased risk of death due to lung cancer. Excessive risk was seen in moderate and severe types of COPD. Lower risk of cancer mortality was seen with COPD patients using statins compared to non users of statins. Likewise, in patients with extra pulmonary cancer with COPD mortality rate were also lower among statin users.

COPD was correlated with increased lung and extra pulmonary cancer mortality in patients suffering from arterial disease who have undergone vascular surgery. Lung cancer mortality is also increased with progression of COPD. Statins reduces the death rate in individuals suffering from lung cancer and extra pulmonary cancer. Thereby it was concluded that the statins are associated with reduced risk of extra pulmonary cancer mortality in patients suffering from COPD.

Source: http://thorax.bmj.com/cgi/content/abstract/64/11/963

Written by: healthplus24.com team

Date last updated: December 07, 2014