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Tobramycin
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General Information
 
Uses
 
What should I know before taking this drug
 
Precautions
 
Dosage information
  
Adverse reactions
 
Storage
 
Additional information if any
 
Tobamist (Cipla)
 

Type: OTC/Prescription/schedule

Tobramycin is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner. 

Pronunciation

Tobramycin pronounced as: toe-bra-MYE-sin
Tobramycin is an anti infective / antibacterial drug belonging to amino glycoside group of antibiotics.
 

Common uses of tobramycin

Tobramycin is used in the treatment of pseudomonas infection in cystic fibrosis patients, respiratory tract infections, urinary tract infection, osteomyelitis, peritonitis skin & soft tissue infections and eye infections.

How to use tobramycin

It is administered intramuscularly or intravenously under strict aseptic precautions as directed by your doctor.

Tobramycin is inhaled into the lungs using a nebulizer. Do not swallow the solution by mouth. Clean all the parts thoroughly after use to prevent contamination.
 
If you are taking other respiratory medication, then take a bronchodilator 1st followed by chest physiotherapy and then Tobramycin inhaler.
 
Take plenty of oral fluids when on Tobramycin medication.
 
Tobramycin should be taken regularly as prescribed by your doctor to attain maximum benefit.
 
Do not skip any doses. Continue to take it even when you feel better.
 
You must complete the entire course of medication to get maximum benefit; else the infection will not clear completely and in due course result in development of resistance.
 
  • Always remember to inform your health expert if you are currently taking any OTC or prescription drugs like
    1. Amphotericin B (Antifungals)
    2. Ethacrynic acid , furosemide (Loop diuretics)
    3. vancomycin, polymyxin B, (Antibiotics)
    4. Cisplatin (Anti cancer drugs)
    5. Cyclosporine (Immunosuppressive drug)
    6. Ibuprofen, Indomethicin ( NSAIDs)
  • Inform your doctor if you have following medical conditions as Tobramycin should be used cautiously in the below mentioned conditions
    1. Renal impairment
    2. Hearing impairment
    3. Parkinson disease
    4. Myasthenia gravis
  • Inform your surgeon or dentist if you are undergoing any planned procedure when on Tobramycin medication as it increases the side effects of the anaesthetic drugs.

When not to take tobramycin

Do not take tobramycin if you are allergic to any other amino glycoside anti biotic. 

What are the precautions I should follow for tobramycin?

Children: Tobramycin medication should be used cautiously in neonates and infants. 

Old people: Tobramycin medication should be used cautiously in elderly individual.
 
Pregnant woman: Tobramycin belongs to FDA pregnancy category D. This means that tobramycin can harm an unborn baby and cause birth defects if used during pregnancy. Do not use tobramycin with out your doctor consent however its use is justified if the benefits to the mother outweigh the risks. Always inform your doctor if you are pregnant or are planning for conception.
 
Lactating women: Tobramycin passes into breast milk and harm nursing baby. Do not use tobramycin with out the consent from your doctor if you are breastfeeding your child.
 
Other:
 

What are the dosage forms tobramycin is available in the market

Tobramycin is available as injection, eye drops and inhaler. Your doctor will prescribe it depending on the severity of the disease. 

Doses for tobramycin

Use as directed by your physician, your physician prescribes depending on the severity of disease. 

Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.

For detailed dosage information, consult your doctor who will prescribe you depending on the severity of the disease. 

What about if I missed the dose of tobramycin

If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose. 

What should I do if I over dosage tobramycin

In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.  

The overdose symptoms of Tobramycin are
  • Giddiness
  • Breathing difficulty
  • Ringing sensation in the ears (tinnitus)
  • Decrease in the amount of urine

What are the common side effects of tobramycin?

Tobramycin may causes following side effects like

  • Redness and pain at the site of injection
  • Dizziness 
  • Loss of appetite
  • nausea & vomiting
  • abdominal pain

When to consult the health expert about the side effects of tobramycin

Consult your doctor immediately if notice following symptoms.

  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes etc
  • Decrease in the amount of urine passed
  • Breathing difficulty
  • Ringing sensation in the ears(tinnitus)
  • Hearing loss
  • Muscle weakness
  • Blurring of vision
  • Convulsions 

How do I store tobramycin?

Store tobramycin at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely. 

What is the most important information I should know about tobramycin

Your doctor may advise you to undergo hearing and renal function tests before and after starting Tobramycin periodically to look for possible side effects. 

Take plenty of oral fluids and strictly avoid dehydration when on Tobramycin.
 
Inform your surgeon or dentist if your undergoing any planned procedure when on Tobramycin medication as it increases the side effects of the anaesthetic drugs.
 
It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information.
 
For possible drug interactions please refer the link below http://www.healthplus24.com/DrugInteraction.aspx
 
Written by: Healthplus24 team
Date: Mar19th,09
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Disclaimer : Every effort has been made to ensure that the information provided by healthplus24 team is accurate, up to date and complete but no guarantee is made to that effect. The information contained herein is intended to supplement not substitute for the expertise and knowledge of health care professional. The information is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, adverse effects etc. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Healthplus24 team disclaims any liability for the decisions you make based on this information.

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  Pregnancy Categories  
 
Category A
Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).

Category B
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Category D
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Category X
Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
 

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