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General information
What should I know before taking this drug?
Adverse reactions
Additional information if any
Selegiline is pronounced as: se-LE-ji-leen
Type: OTC / Prescription
Selegiline is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner.
Selegiline belongs to the class of drugs called monoamine oxidase inhibitors.
Selegiline is an anti depressant drug.
  • Selegiline is used to treat depression.
  • Selegiline is also used to treat symptoms of Parkinson’s disease.
  • Use Selegiline as instructed on the label or as prescribed by the doctor. Do not take the drug in more or less amounts.
  • Selegiline should be taken without food.
  • If you are taking an orally disintegrating tablet (ODT), do not drink water either before or after the consumption of the tablet. Keep the tablet on your tongue and allow it to dissolve completely on its own. Do not swallow the ODT.
  • Use of selegiline should not be stopped suddenly, as this may worsen your condition. If you want to discontinue it, start by slowly reducing your dosage. However, it is best to consult your doctor before you stop taking this medication. At times it is advised to continue with the medication even if you feel well.
  • Selegiline takes a few weeks to take full affect. In order to improve your condition, use the drug as long as directed by the physician.
Children: Safety and effectiveness of selegiline is not confirmed in children. Extreme caution is required while usage in children.

Older people: Use under the supervision of physician as they are more sensitive to adverse effects of selegiline.  

Pregnant women: Selegiline belongs to FDA pregnancy category C. This means that selegiline may harm an unborn baby if used during pregnancy but potential benefit may warrant use of the drug in pregnant woman despite potential risks. Always inform your doctor if you are pregnant or are planning for conception.

Lactating women: It is not known whether selegiline passes into breast milk or if it could harm the baby. Do not take selegiline with out first talking to doctor if you are breast feeding a baby.
  • Use selegiline under strict medical supervision.
  • Before starting the treatment, inform your doctor if you have any medical history related to heart disease, glaucoma, asthma, liver problems and kidney problems. Also inform him of any personal or family medical history of any other mental/mood conditions as well as the list of substances you are allergic to.
  • In case if you have diabetes, inform your physician before hand as during selegiline treatment blood sugar levels may become uncontrolled.
  • Before any surgery, inform your doctor/dentist that you are using this medication.
  • As the drug causes dizziness and lightheadedness do not handle heavy machinery and do not drive during the treatment.
  • During the treatment, do not rise suddenly from sitting position as it may cause excess dizziness. Avoid activities that require alertness of mind.
  • As the patient may experience different mental conditions during the treatment, it is advised that the family members keep the patient under constant care. This is because during the treatment the patient may develop suicidal tendency.
Common side effects of selegiline include:
  • Dry mouth
  • Blurred vision
  • Headache, Drowsiness, Dizziness
  • Constipation
  • Nausea, Vomiting
  • Loss of appetite
  • Stomach cramps
How do I store selegiline
Store selegiline at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.
  • Before starting the treatment, provide your doctor the list of medications that are consumed by you. This is done to avoid any serious drug interaction with selegiline.
  •  Consult your doctor and be aware of the diet you need to take during selegiline treatment.
  • Avoid using Tyramine while taking selegiline. Tyramine in combination with selegiline may increase your blood pressure and cause other life threatening symptoms.
  • Do not stop the consumption of selegiline suddenly as it may cause serious side effects. Use the medication as prescribed by the doctor. Consult your doctor if you want to stop the medication.

Written by: Healthplus24 team
Date last updated: August 30,2009