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General Information
What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any
Arbid (Hetero HC)
Roximin (Reliance) 
Roxithromycin is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner. 
Roxithromycin pronounced as: rox-ZITH roe MYE sin 
Roxithromycin is an anti infective / antibacterial drug belonging to Macrolide group of antibiotics. 
Roxithromycin is used in the treatment of respiratory tract infection, infections of ear, nose &throat 
Take roxithromycin exactly as prescribed by your doctor. If you do not understand ask your pharmacist, nurse or doctor to explain them to you.
Take oral dose of roxithromycin on empty stomach 1hr before or 2hrs after meals with 1 glass of water at regular intervals as prescribed by your doctor.
Do not skip any doses. Continue to take it even when you feel better.
You must complete the entire course of medication to get maximum benefit; else the infection will not clear completely and in due course result in development of resistance.
  • Do not take roxithromycin if you are taking following medication as it can cause life threatening cardia arrhythmias
    1. Cisapride
    2. Astemizole (antihistamine)
    3. Terfenadine (antihiatmine)
    4. Pimozide
  • Roxithromycin is known to interact with wide variety of drugs. Inform your doctor if you are taking any OTC or prescription medicine like
    1. Anticoagulants (warfarin)
    2. Anti migraine drugs(ergotamine)
    3. Anti convulsants (carbamazepine, phenytoin)
    4. Anti hypertensive like sotalol,felodipine,
    5. Cholesterol lowering drugs( lovastatin)
    6. HIV drugs(Nelfinavir, Indinavir)
  • Inform your doctor if you have following medical conditions as roxithromycin should be used cautiously in the below mentioned conditions
    1. Liver disease
    2. Kidney disease
    3. Blood disorder- Porphyrias
    4. History long QT syndrome
    5. History of cardiac arrhythmias
Do not take roxithromycin if you are allergic to any macrolide group of antibiotics.
Old people:
Pregnant woman: Roxithromycin belongs to FDA pregnancy category B. This means that roxithromycin is safe during pregnancy and is not expected to cause any harm to the unborn baby. Always inform your doctor if you are pregnant or are planning for conception.
Lactating women: It is not known whether roxithromycin passes into breast milk or if it could harm the baby. Do not take roxithromycin with out first talking to doctor if you are breast feeding baby.
Roxithromycin can decrease the efficacy of combination type birth pills. Consult your doctor regarding other effective contraceptives like condom, diaphragm, spermicidal gels etc to avoid pregnancy. 
Roxithromycin is available as tablet, suspension, ear drops and injection. Your doctor will prescribe them depending on the severity and condition of the disease. 
Use as directed by your physician, your physician prescribes depending on the severity of disease.
Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.
For detailed dosage information, consult your doctor who will prescribe you depending on the severity of the disease. 
If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose. 
In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.
The overdose symptoms of roxithromycin are not known. 
Roxithromycin may causes following side effects like
  • Diarrhoea 
  • Ringing sensation in the ears(tinnitus)
  • Nausea and vomiting 
  • Sleep disturbance
Consult your doctor immediately if notice following symptoms.
  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes peeling of skin, blistering etc
  • Severe diarrhoea associated with bloody stools
  • Jaundice( yellowing of eyes and skin)
  • Palpitations, irregular heartbeat
  • Decrease in hearing ability
Store roxithromycin at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely. 
Roxithromycin sensitizes the skin to sunlight. Avoid prolong exposure or use long sleeved clothing and sunscreen (SPF-15) when you go out in the sun.
Antibiotics usually cause mild diarrhoea. Consult your doctor immediately if it is severe, associated with mucus or bloody stools, as it could be sign of new infection or pseudomembranous colitis.

When used for long duration, your doctor may ask you to undergo laboratory test like complete cell count, liver function test, Renal function test to look for possible side effects.

It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information.

Written by: Healthplus24 team
Date last updated June 11, 2012