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General Information
What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any
Rhythmonorm tab (Zy.Cad (G.Rem)) 
Propafenone is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner. 


Propafenone pronounced as: proe-pa-FEEN-none

What is propafenone?

Propafenone is an anti arrhythmic drug. 
Propafenone is used to treat symptomatic heart rhythm disturbance like Paroxysmal Supra ventricular Tachycardia (PSVT) and Paroxysmal atrial fibrillation/ flutter.
  • Take Propafenone exactly as prescribed by your doctor. If do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
  • Take oral dose of Propafenone with meals with one glass of water at regular intervals to be effective.
  • Do not take Propafenone in larger amounts or for longer duration than recommended by your doctor. 
  • Do not skip doses or stop taking Propafenone without consulting your doctor. Stopping suddenly may worsen cardiac arrhythmias.
  • Propafenone injection should be given under medical supervision with provision for cardiac monitoring.
  • Propafenone is known to interact with wide range of drugs. Always remember to inform your health expert if you are currently taking any OTC or prescription drugs like,
    1. Rifamipicin ( anti TB drug)
    2. Ritonavir (HIV drug)
    3. Warfarin ( oral anticoagulant)
    4. Digoxin
    5. Other antiarrythmic drugs like Flecainide, procainamide, lidocaine quinidine
    6. Cimetidine (gastric medication)
    7. theophylline ( anti asthma drug)
    8. Anti convulsants like phenytoin, phenobarbitone
    9. beta blockers like metoprolol, propranolol
  • Inform your doctor if you have following medical diseases , as Propafenone should be used cautiously in these conditions
    1. Congestive heart failure
    2. Myasthenia gravis
    3. History of heart block and without pace maker
    4. Sinus node disease
    5. Liver disease
    6. Electrolyte disturbances
    7. chronic bronchitis
Do not take propafenone if you have heart problems like irregular heart beat and bradycardia. 
Old people:
Pregnant woman: Propafenone belongs to FDA pregnancy category C. This means that propafenone may harm an unborn baby if used during pregnancy but potential benefit may warrant use of the drug in pregnant woman despite potential risks. Always inform your doctor if you are pregnant or are planning for conception.
Lactating women: It is not known whether propafenone passes into breast milk or if it could harm the baby. Do not take propafenone with out first talking to doctor if you are breast feeding a baby.
Avoid eating grape fruit or drink grape juices when on Propafenone 
Propafenone is available as injection and tablet. Your doctor will prescribe it depending on the severity of the condition. 
Use as directed by your physician, your physician prescribes depending on the severity of disease.
Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication. 
If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose.
In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.
The overdose symptoms of Propafenone are
  1. Very slow heartbeat
  2. Extreme weakness
  3. Fainting
  4. convulsions
Propafenone may cause following side effects 
  • Giddiness 
  • Loss of appetite
  • Abnormal taste sensation
  • Fatigue 
  • Tremors
Consult your doctor immediately if notice following symptoms.
  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes. Peeling of skin etc
  • Fever ,chills, sore throat
  • Slow heart rate
  • Chest pain, shortness of breath
  • Visual disturbances
  • Easy bruising or bleeding
Store propafenone at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.
  • Propafenone causes dizziness, blurring of vision. Hence when affected avoid alcohol and activities which requires you to be alert like driving, operating heavy machinery.
  • If you have an artificial pace maker get it monitored regularly as it may affect its functioning
  • Regular monitoring of ECG (electrocardiogram), blood cell counts, electrolyte levels is required when on propafenone.
  • Visit your doctor regularly for monitoring your blood pressure, pulse rate and heart rhythm when taking propafenone.
  • Adopt healthy lifestyle changes like regular exercise, healthy diet; quit smoking, alcohol to improve your overall health. 
It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information. 

Written by: Healthplus24 team
Date: Mar25th,09 

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