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General Information
What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any
Pipralin (United Biotech)
Pracil ( Neon Labs) 
Piperacillin is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner. 
Piperacillin pronounced as: PI-per-a-SIL-in 
Piperacillin is an anti infective / broad spectrum antibacterial drug belonging to penicillin group of antibiotics. 
Piperacillin is used in the treatment of serious bacterial infections, uncomplicated gonorrhoea, to prevent infections during and after surgery. 
Piperacillin vial should be inspected visually for particulate matter prior to administration.
Preparations of Piperacillin containing visibly opaque particles should NOT be used.
Piperacillin is administered intravenously under strict aseptic condition exactly as directed by your doctor.  

Piperacillin should be taken regularly as prescribed by your doctor to attain maximum benefit.

Do not skip any doses. Continue to take it even when you feel better. 

You must complete the entire course of medication to get maximum benefit; else the infection will not clear completely and in due course result in development of resistance.
  • Always remember to inform your health expert if you are currently taking any OTC or prescription drugs like
    1. Anticoagulants like warfarin, heparin
    2. Tetracycline’s (eg.doxycycline)
    3. Aminoglyoside antibiotics like Tobramycin
    4. Loop diuretics like furosemide, hydrochlorothiazide
  • Inform your doctor if you are allergic to other penicillin drugs (e.g. amoxicillin, carbenicillin) and Cephalosporin drugs (cefaclor, cephaloridin) as it may cause allergic reaction in these patients.
  • Inform your doctor if you have following medical conditions as Piperacillin should be used cautiously in the below mentioned conditions
    1. Renal impairment
    2. Low potassium levels
    3. Bleeding disorder
    4. Bowel inflammation
Do not take Piperacillin if you are allergic to any other penicillins.
Do not take Piperacillin along with tetracyclines.

Old people: Piperacillin medication should be used cautiously in elderly individual as their renal function decreases with advancing age.

Pregnant woman: Piperacillin belongs to FDA pregnancy category B. This means that piperacillin is safe during pregnancy and is not expected to cause any harm to the unborn baby. Always inform your doctor if you are pregnant or are planning for conception.
Lactating women: It is not known whether piperacillin passes into breast milk or if it could harm the baby. Do not take piperacillin with out first talking to doctor if you are breast feeding baby.
Piperacillin decreases the efficacy of birth pills. Consult your doctor regarding other methods of contraception. 
Piperacillin is available as injection. 

Doses for piperacillin

Use as directed by your physician, your physician prescribes depending on the severity of disease. 

Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.
For detailed dosage information, consult your doctor who will prescribe you depending on the severity of the disease. 
If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose. 
In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.
The overdose symptoms of Piperacillin are Convulsions and Excitability  
Piperacillin may causes following side effects like
  • Diarrhoea 
  • Nausea and vomiting
  • Abdominal pain
  • Pain, redness and swelling at the site of injection
Consult your doctor immediately if notice following symptoms.
  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes. Peeling of skin etc
  • Decrease in the amount of urine passed
  • Persistent sore throat
  • Easy bruising or bleeding
  • Severe diarrhoea, Blood or mucus in the stools
  • Convulsions 
  • Jaundice (yellowing of skin & eyes)
Store piperacillin at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely. 
Antibiotics may cause diarrhoea. Consult your doctor immediately if it is very severe as it could be a sign of new infection or pseudomembranous colitis.
Regular monitoring of body electrolytes, liver function tests, renal function tests, and complete cell count is required when on Piperacillin medication to look for possible side effects.

Piperacillin may cause false positive in urine sugar. If you are diabetic on Piperacillin medications inform lab personnel prior to the test.

It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information.


Written by:  Healthplus24 team
Date: Mar6th,09

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