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General Information
What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any
Mozep tab (Intas)
R zep tab (Reliance) 
Pimozide is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner. 
Pimozide pronounced as: PI-moe-zide 
Pimozide is an anti psychotic medication. 
Pimozide is used in the treatment of severe muscle tics and speech tics in patients of Tourette’s syndrome in whom other medicines have been ineffective.
  • Take Pimozide exactly as prescribed by your doctor. If do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
  • Take Pimozide at regular intervals as advised by your doctor for it to be effective.
  • Avoid eating grape fruit or drink grape juices when on Pimozide medication.
  • Do not take the medication in larger amounts or for longer duration than recommended by your doctor.
  • Do not skip doses or stop taking Pimozide without consulting your doctoras it may worsen your condition.
  • Always remember to inform your health expert if you are currently taking any OTC or prescription drugs like,
    1. Antiarrythmic drugs like quinidine
    2. Anti convulsants like phenytoin. Phenobarbitone, carbamazepine
    3. Antibiotics like erythromycin, Rifampicin
    4. Anti fungals like Itraconazole, ketoconazole
    5. Anti HIv drugs like Zidovudine, ritonivir etc
    6. Anti hypertensive’s or other heart medication
  • Inform your doctor if you have following medical diseases , as Pimozide should be used cautiously in these conditions
    1. Family history prolonged QT interval
    2. Cardiac arrhythmias
    3. Parkinson’s disease
    4. Seizure disorder
    5. Electrolyte disturbances
    6. Renal impairement
Do not take pimozide if you are allergic to it. 
Old people:
Pregnant woman: Pimozide belongs to FDA pregnancy category C. This means that pimozide may harm an unborn baby if used during pregnancy but potential benefit may warrant use of the drug in pregnant woman despite potential risks. Always inform your doctor if you are pregnant or are planning for conception.
Lactating women: It is not known whether pimozide passes into breast milk or if it could harm the baby. Do not take pimozide with out first talking to doctor if you are breast feeding a baby.
Pimozide is available in the form of tablets. 
Use as directed by your physician, your physician prescribes depending on the severity of disease.
Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication. 
If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose. 
In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.
The overdose symptoms of Pimozide include
  • Dilated or constricted pupils
  • Breathing difficulty
  • Muscle stiffness
  • Tremors
  • Weakness 
  • Irregular heart rate
Pimozide may cause following side effects
  • Drowsiness 
  • Dryness of mouth
  • Constipation 
  • Difficulty in falling sleep (insomnia)
Consult your doctor immediately if notice following symptoms.
  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes. Peeling of skin etc
  • Irregular heart rate
  • Blurring of vision
  • Muscle stiffness
  • Fever, difficulty in swallowing
  • Tremors , drooling, increased anxiety, restlessness (extra pyramidal symptoms)
  • Decrease sexual interest in males
  • Uncontrolled movements of the hands, legs, tongue, face
Store pimozide at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely. 
  • Before starting Pimozide your doctor may advise you to undergo Electro cardiogram (ECG) to look for any heart rhythm disturbances.
  • Avoid getting dehydrated or extreme heat as pimozide may increase the risk of having heat stroke. Take plenty of oral fluids in hot weather and during exercise
  • Pimozide causes giddiness, drowsiness and visual disturbances as side effects. Therefore when affected do not drive, operate heavy machinery or perform unsafe tasks.
  • Pimozide may rarely cause a group of symptoms called as Neuroleptic Malignant syndrome (NMS) characterised by difficulty in swallowing, Muscle stiffness, rapid heart rate, visual disturbances, fever, sweating etc. Stop the drug immediately and consult your doctor.
  • Regular monitoring of your heart function (ECG) and blood potassium and magnesium levels is required when on this medication to look for possible side effects. 
It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information. 

Written by: Healthplus24 team
Date: Mar01st,09