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General Information
What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any
Pentovas tab (Lincoln)
Flexital tab (Sun) 
Pentoxifylline is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner. 
Pentoxifylline pronounced as: pen-tox-IH-fi-leen 
Pentoxifylline is a coagulation modifying drug and blood flow enhancer. 
Pentoxifylline is used for symptomatic relief of leg pain due to walking (intermittent Claudication) in disorder of blood circulation (Peripheral Vascular disease), to improve blood flow in cerebrovascular insufficiency, arteriosclerosis etc. 
  • Take Pentoxifylline exactly as prescribed by your doctor. If do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
  • Take Pentoxifylline preferably with meals or antacid with a full glass of water to avoid gastric upset. 
  • Do not take the medication in larger amounts or for longer duration than recommended by your doctor. 
  • Do not skip doses or stop taking Pentoxifylline without consulting your doctor. 
  • Pentoxifylline may take up to 2-8week to show its beneficial effects. However continue to take the medication regularly and consult your doctor if your symptoms do not improve even after regular medication.
  • Always remember to inform your health expert if you are currently taking any OTC or prescription drugs like,
    1. Other blood thinning medication like aspirin, warfarin, Ticlopidine
    2. Antihypertensives
    3. theophylline
    4. Insulin and or oral Hypoglycaemic drugs 
  • Inform your doctor if you have history of bleeding in the retina or are allergic to methyl xanthines( caffeine, theophylline, bromine) as Pentoxifylline should not be used in this conditions.
  • Inform your doctor if you have following medical diseases , as Pentoxifylline should be used cautiously in these conditions
    1. Bleeding disorder
    2. Acid Peptic disease
    3. Recent history of surgery
    4. Renal disease
    5. Diabetic
Do not take pentoxifylline if you had cerebral haemorrhage or retinal haemorrhage 
Old people:
Pregnant woman: Pentoxifylline belongs to FDA pregnancy category C. This means that pentoxifylline may harm an unborn baby if used during pregnancy but potential benefit may warrant use of the drug in pregnant woman despite potential risks. Always inform your doctor if you are pregnant or are planning for conception.
Lactating women: It is not known whether pentoxifylline passes into breast milk or if it could harm the baby. Do not take pentoxifylline with out first talking to doctor if you are breast feeding a baby.
Pentoxifylline is available in the form of tablet and injection. 
Use as directed by your physician, your physician prescribes depending on the severity of disease.
Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication. 
If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose. 
In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.
The overdose symptoms of Pentoxifylline are
  1. fever
  2. Restlessness
  3. convulsions
  4. drowsiness
Pentoxifylline may cause following side effects 
  • Headache 
  • Flushing
  • Sleep disturbances
  • Nausea , vomiting, Belchings
  • Dizziness
Consult your doctor immediately if notice following symptoms.
  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes. Peeling of skin etc
  • Easy bruising or bleeding
  • Jaundice (yellowing of eyes and skin)
  • Chest pain, palpitations, shortness of breath
  • Irregular heartbeat
  • Blurring of vision
Store pentoxifylline at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.
  • Pentoxifylline can cause dizziness as side effect. Avoid activities like driving, operating heavy machinery which require you to be alert.
  • Inform your doctor or dentist regarding pentoxifylline medication prior to any procedure.
  • Visit your doctor regularly for monitoring your progress and for lab test (liver function test, blood tests) to look for possible side effects of pentoxifylline.
  • Smoking and tobacco chewing can worsen the intermittent claudication pain. Quit smoking for improving the symptoms and your overall health.
  • Regular moderate exercise helps in improving the blood circulation and pain relief. Consult your doctor regarding the type of exercise suitable for you.
  • Eat a healthy low fat diet as cholesterol deposition in the arteries (atherosclerosis) may decrease the blood flow and worsen the symptoms. 
It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information. 

Written by: Healthplus24 team
Date: Mar22nd,09 

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