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What is pefloxacin

This is a fluroquinolone antibiotic that is prescribed for treatment of gonococcal urethritis in men.

It is also prescribed in case of gram-negative bacterial infections of the gastrointestinal system and genitourinary tract.

Brand names with manufacturer

Isofloxin, Pefloxacin, Lobocton, Pelox (100 ml), Proflox Drops, Aviflox


Prescription drug.

Uses of pefloxacin


Pefloxacin is prescribed to treat:

  • Uncomplicated gonoccoal urethitis in men
  • Gram-negative as well as gram-positive bacterial infections of the gastrointestinal system
  • Bacterial infections of the genitourinary tract
  • It was used to treat Gonorrhoeae infection at one time. However, bacterial resistance has rendered Pefloxacin ineffective.
  • Other

Pefloxacin is used to treat microbial infections in animals.

What should I know before taking pefloxacin

How to take it

Pefloxacin is to be taken by mouth with food.

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Adverse reactions/side effects

The side effects of Pefloxacin include allergic reactions. It leads to swelling of the lips, mouth, face, tongue; hives; breathing difficulty.

Other side effects includes:

Do not take the medicine in case of hypersensitivity, pregnancy or when nursing a baby.

Precautions for pefloxacin


Children under 12 years of age are not  given Pefloxacin

Geriatric use

The effects on older people is similar to those given to young adults.

Pregnant women

The drug belongs to Category Pregnancy N. Its effect on pregnancy are not known. Thus, one should avoid giving it to a pregnant mother or women who are planning for pregnancy.

Lactating women

The use of Pefloxacin in lactating women is contradicted. Thus, do not give the drug to a lactating mother.


Avoid giving the drug to patients with a history of brain or spinal cord disease. Avoid prescribing it to patients with kidney disease, liver impairment or epilepsy.

What should I do if

I miss dose(s)

If you miss a dose, take it immediately when you remember about it. Do not take it, if it is time for a second dose. Never double dose on Pefloxacin.

I take an overdose

If you overdose, call your physician immediately and seek medical help if you show adverse reactions.

What to discuss with the doctor/pharmacist

Drug interactions

Pefloxacin may show drug reactions when taken with other drugs such as aminophylline, calcium complexes, iron complexes, magnesium complexes, oxtriphylline, theophylline, etc.

Thus, discuss with  your doctor all the drugs you have been taking before you take Pefloxacin.

Dosage form

Pefloxacin is available in the form of tablets as well as an IV infusion.

Dosage of pefloxacin

Adults should be given tablets of 400 mg for 7 to 10 days along with food. In case of IV Influsion, adults are given 400 mg of Pefloxacin in 100 ml of 5% dextrose slow infusion over an hour.


Store the drug at room temperature. Keep away from heat and moisture.

Additional information, if any

Avoid the sun after taking the drug. It can lead to severe sunburns.

Written by: team

Date last updated: June 08, 2015