Nalidixic acid

Brand names and manufacturer

Gramoneg (Ranbaxy(Pharma), Negadix (CFL)

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Type: OTC/Prescription/schedule

Nalidixic acid is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner.

Pronunciation

Nalidixic acid pronounced as: nal-i-DIX-ik AS-id

What is nalidixic acid?

Nalidixic acid is an anti infective / antibacterial drug belonging to a Quinolone group of antibiotics.

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Common uses of nalidixic acid

Nalidixic acid is used in the treatment of Urinary tract infection and shigellosis.

How to use nalidixic acid

Take nalidixic acid exactly as prescribed by your doctor. If you do not understand ask your pharmacist, nurse or doctor to explain them to you.

Take oral dose of nalidixic acid after meals with 1 glass of water at regular intervals as prescribed by your doctor.

Avoid taking antacids containing aluminum, zinc, magnesium along with nalidixic acid as it decreases its absorption. However you may take it 2hr before or 2 hrs after taking Nalidixic acid.

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Do not skip any doses. Continue to take it even when you feel better.

You must complete the entire course of medication to get maximum benefit; else the infection will not clear completely and in due course result in development of resistance.

What should I discuss with my health care provider before taking nalidixic acid?

Inform your doctor if you are using any OTC or any prescription drugs like

  • Oral anti coagulants( warfarin)
  • Anti cancer drugs (melphalan)
  • Probenecid
  • Anti arrhythmic drugs ( amiodarone,sotalol)
  • Immunosuppressive drug (cyclosporine)

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Inform your doctor if you have following medical conditions as Nalidixic acid should be used cautiously in the below mentioned conditions

  • Seizure disorder
  • Blood disorder ( Porphyria)
  • Cardiac arrhythmias
  • Central nervous system disease, hardening of cerebral arteries
  • Glucose 6 phosphate dehydrogenase (G6PD) deficiency

When not to take nalidixic acid

Do not use nalidixic acid if you ever has convulsions or porphyria.

What are the precautions I should follow for nalidixic acid?

Children: Nalidixic acid should be used cautiously in children younger than 18 yrs as the risk of side effects is more.

Old people: Nalidixic acid should be used cautiously in and in elderly individual as the risk of side effects is more.

Pregnant woman: Nalidixic acid belongs to FDA pregnancy category C. This means that nalidixic acid may harm an unborn baby if used during pregnancy but potential benefit may warrant use of the drug in pregnant woman despite potential risks. Always inform your doctor if you are pregnant or are planning for conception.

Lactating women: It is not known whether nalidixic acid passes into breast milk or if it could harm the baby. Do not take nalidixic acid with out first talking to doctor if you are breast feeding a baby.

Other:

Nalidixic acid can cause drowsiness and impair thought process. Avoid activities which require you to be alert.

What are the dosage forms nalidixic acid is available in the market

Nalidixic acid is available as tablet, suspension. Your doctor will prescribe it depending on the severity of the disease.

Doses for nalidixic acid

Use as directed by your physician, your physician prescribes depending on the severity of disease.

Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.

For detailed dosage information, consult your doctor who will prescribe you depending on the severity of the disease.

What about if I missed the dose of nalidixic acid

Use as directed by your physician, your physician prescribes depending on the severity of disease.

Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.

For detailed dosage information, consult your doctor who will prescribe you depending on the severity of the disease.

What should I do if I over dosage nalidixic acid

in case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.

The overdose symptoms of nalidixic acid are convulsions.

What are the common side effects of nalidixic acid?

Nalidixic acid may causes following side effects like

  • Diarrhea
  • Drowsiness
  • Nausea, vomiting
  • Headache
  • Giddiness
  • Increased sensitivity to sunlight

When to consult the health expert about the side effects of nalidixic acid

Consult your doctor immediately if notice following symptoms.

Allergic reaction like swollen lips, hives, difficulty in breathing, rashes peeling of skin, blistering etc

Severe diarrhea associated with bloody stools

Visual disturbances

Tingling and numbness in extremities

Pain, redness or stiffness in joint/ tendon

Loss of pain, temperature and position sense

How do I store nalidixic acid?

Store nalidixic acid at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.

Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.

What is the most important information I should know about nalidixic acid

Antibiotics usually cause mild diarrhea. Consult your doctor immediately if it is severe, associated with mucus or bloody stools, as it could be sign of new infection or pseudomembranous colitis.

Regular monitoring of blood cell count, hepatic and renal function is required when Nalidixic acid is used for prolonged period (> 2wks).

Avoid prolonged sun exposure as Norfloxacin sensitizes the exposed skin causing burning sensation, rash etc. Use long sleeved clothes, sunscreen lotion (SPF-15) when you go out in sun to avoid photo toxicity.

It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information.