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General Information
What should I know before taking this drug
Dosage information
Adverse reactions

Brand names and manufacturer
Metoral tab (Dr. Reddy’s)
Diurem tab (Cipla)

Metolazone is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner.
Metolazone pronounced as: meh-TOLE-uh-ZONE

What is metolazone?
Metolazone (pronounced as: meh-TOLE-uh-ZONE)) is a Thiazide diuretic which helps in removing fluid from the body. Hence, it’s also known as “water-pill”.

Metolazone is used in treatment of hypertension & excessive fluid retention as in cardiac failure, cirrhosis, chronic renal failure, Nephrotic syndrome, Cushing’s disease.
  • Take Metolazone exactly as prescribed by your doctor. If do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
  • Do not take the medication in larger amounts or for longer duration than recommended by your doctor. Take this medication with a full glass of water.
  • Take Metolazone preferably during daytime to avoid waking up during night for urination. 
  • Do not skip doses or stop taking Metolazone without consulting your doctor. Stopping suddenly may worsen hypertension.
  • Inform your doctor if you are allergic to sulpha drugs like sulphamethoxazole, hydrochlorothiazide etc as it may cause allergic reaction in these patients also.
  • Always remember to inform your health expert if you are currently taking any OTC or prescription drugs like,
    1. Lithium (mood stabilizer)
    2. Insulin or oral hypoglycaemic drugs
    3. NSAIDs(Non steroidal anti inflammatory drugs) like aspirin, Ibuprofen, Diclofenac etc
    4. Corticosteroids like prednisone
    5. Cholesterol lowering drugs like Cholestyramine, Colestipol
    6. Digoxin
    7. Other Anti hypertensive drugs
  • Inform your doctor if you have following medical diseases , as Metolazone should be used cautiously in these conditions
    1. Liver disease
    2. Kidney disease
    3. Anuria( passing no urine at all)
    4. Diabetes
    5. Gout
Do not take metolazone in anuria ( unable to urinate) and in hepatic impairment.
Old people:
Pregnant woman: Metolazone belongs to FDA pregnancy category B. This means that metolazone is safe during pregnancy and is not expected to cause any harm to the unborn baby. Always inform your doctor if you are pregnant or are planning for conception.
Lactating women: It is not known whether metolazone passes into breast milk or if it could harm the baby. Do not take metolazone with out first talking to doctor if you are breast feeding baby.
If you are diabetic and on metolazone, keep a close watch on your blood glucose levels.
Visit your doctor regularly for monitoring your blood pressure and pulse rate when taking metolazone.
Metolazone is available in the form of tablet.
Use as directed by your physician, your physician prescribes depending on the severity of disease.
Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.
If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose.
In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.
The overdose symptoms of Metolazone are
  1. Muscle cramps
  2. Very dry mouth , increased thirst
  3. Fainting
  4. Fatigue
Metolazone may cause following side effects
  • Blurring of vision 
  • Giddiness 
  • Pain in the joints
  • Headache
Consult your doctor immediately if notice following symptoms.
  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes. Peeling of skin etc
  • Increased thirst, dry mouth
  • Muscle pain & weakness 
  • Numbness & tingling sensation
  • Extreme weakness, drowsiness, irritability
  • Fast irregular heartbeat

How do I store metolazone?
Store metolazone at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.

  • Avoid extreme heat and getting dehydrated during exercise when on Metolazone.
  • Inform your surgeon regarding Metolazone medication prior to any surgery as it may have to be stopped for a brief period for surgery.
  • Your doctor may prescribe potassium supplement along with Metolazone medication as it depletes potassium from the body. Do not increase or decrease the dose without your doctor’s advice
  • Regular monitoring of body electrolyte is required when on Metolazone to look for side effects.
  • Metolazone sensitizes the skin to sunlight. Avoid prolong exposure to sunlight or wear long sleeved clothing& use sunscreen when you go out in sun.
  • Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life.
  • Adopt healthy lifestyle changes like regular exercise, healthy diet, quit smoking, alcohol to lower your blood pressure and improve your overall health.

It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information.

Written by: Healthplus24 team
Date last Updated: July 7, 2011