Lincomycin pronounced as: LIN koe mye sin

What is it

Lincomycin is used to treat bacterial infections. It is a lincomycin antibiotic that is used for patients who are allergic to penicillin antibiotics. Lincomycin is prescribed only in cases of severe infections.

Brand names with manufacturer

Lincocin Type:

It is a prescription drug that is sold at retail counters.



Lincomycin is used to treat bacterial infections that include mild diarrhea to fatal colitis. It is a lincosamide antibiotic that is produced from Streptomyces lincolnensis. Lincomycin has similar structural properties like other drugs in the antibacterial spectrum. It is effective against actinomycetes, Mycoplasma, and certain Plasmodium sp.


Lincomycin tends to stop the production of certain important proteins in the bacteria that leads to the cell death. However, the drug can alter the normal flora of the intestines, and may lead to serious and fatal form of diarrhea called pseudomembranous colitis. Thus, the use of drug today is very limited and only in necessary cases.

What should I know before taking this drug

How to take it

Lincomycin should be taken with a glass of water on and an empty stomach. This means 1 hour before the meal or 2 hours after the meal. Use the drug as directed as your physician.

Never stop the drug before completing the course, even if the symptoms clear off or you feel better. Never skip or forget a dose. The effectiveness of lincomycin depends on the constant amount of the drug in the blood. Space each drug dose evenly throughout the day and night.

Adverse reactions/side effects

It is quite usual to observe mild diarrhea after using antibiotics. Linomycin may also lead to mild diarrhea. Other side effects of lincomycin that do not require medical attention include:

  • Dizziness
  • Nausea
  • Pain or irritation at site of injection
  • Vomiting

Side effects that require immediate medical attention include:

  • Severe allergic reaction like rash, hives, swelling of face, mouth, lips, tongue. Etc.
  • Bloody or watery stools
  • Problems swallowing
  • Dizziness
  • Irritation in the mouth
  • Ringing in ears
  • Persistent diarrhea
  • Change in the amount of urine passed
  • Swelling in hands, legs, eyes
  • Yellowing of skin or eyes

Some of the serious side effects may occur several days after taking or stopping the drug.

When not to take the medicine

Do not use lincomycin, if:
You are allergic to any ingredient found in the drug
If you are on erythromycin



Lincomycin has been used in some children and according to reports, it is found to be safe and effective antibiotic for infections against Gram-positive cocci.

Old people

The drug has been found to be tolerated less well in older patients than in younger patients. Thus, the geriatric use of lincomycin should be monitored carefully.

Pregnant women

One needs to discuss with their doctor if they are pregnant or planning to become pregnant, before taking the drug.

Lactating women

Lincomycin is excreted in breast milk. Thus, do not nurse a baby when using lincomycin.


Lincomycin contains benzyl alcohol. Thus, it should not be used in newborns and infants.
It may cause severe skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis. Thus, seek immediate medical attention if you develop redness, blisters, swelling, peeling of skin, fever, irritated eyes, mouth sores, etc.
Long term use is not advised as it may lead to secondary infection.

What should I do if

I miss dose(s)

Take the dose immediately when you remember about it. If it is time for the next dose, skip the one missed. Never double dose on lincomycin.

I take an overdose

If you suspect an overdose, call the emergency medical help immediately.

What to discuss with the doctor/pharmacist

Inform your doctor about any prescription or nonprescription medicines that you may be taking. This includes herbal supplements, vitamin supplements, etc. Also, inform the doctor about any food, drug or other substance allergy you may have.

Drug interactions

Lincomycin has been reported to show neruromuscular blocking properties. This may enhance the effect of neuromuscular blocking agents. Thus, it should be used cautiously in patients receiving such drugs.
Also, there have been antagonistic properties demonstrated between lincomycin and erythromycin in vitro. Thus, do not use these drugs together.

Dosage form

Capsule and solution form.


The dose depends on different patients and the severity and type of infection. In case of capsules, adults and teenagers are prescribed 500 mg every 6 to 8 hours. For children, it is calibrated according to body weight.
In form of injection, adults and teenagers are injected 600 mg to 1 gram of lincomycin in the vein for over at least 1 hour every 8 to 12 hours. 600 mg of lincomnycin can also be injected into a muscle every 12 to 24 hours. Children are given a dose measured according to their body weight.


Store the medicine at room temperature in a tightly closed container. Keep away from children and pets. Do not freeze.

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