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General Information
Brand names and manufacturer
Type: OTC/Prescription/schedule

What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any
Note: Glibenclamide is also know as glyburide


Glibenclamide is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner.


Glibenclamide is oral anti diabetic medication belongs to sulfonylurea group of drugs.

Glibenclamide is used to treat type 2 diabetes (Non insulin dependent diabetes) 

  • Take glibenclamide exactly as prescribed by your doctor. If you do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
  • Do not take the medication in larger amounts or for longer duration than recommended by your doctor.
  • Do not stop taking this medication unless advised by your doctor. 
  • Take the glibenclamide with food at breakfast time or with main meal.

What should I discuss with my health care provider before taking glibenclamide? 

  • Always remember to inform your doctor or pharmacist if you are currently taking any OTC drugs or prescription drugs like bosentan, beta blockers like atenolol, warfarin, ketoconazole, NSAIDs 
  • This may not be the complete list of drugs interact with glibenclamide, ask your pharmacist if any other drugs interact with this medication. 
  • Inform your doctor or pharmacist if you have any of the following medical conditions as glibenclamide should be cautiously used.  
    1. Liver disease
    2. Kidney disease
    3. Heart problems
    4. Thyroid problems 

Do not take glibenclamide

  • If you are allergic to it.
  • If you are suffering with diabetic ketoacidosis.
  • If you have type 1 diabetes

What are the precautions I should follow for glibenclamide?

Children: Glibenclamide should not be used in children.

Old people: Older people are more sensitive to hypoglycemic effect of glibenclamide. The dosing should be monitored.

Pregnant woman: Glibenclamide belongs to FDA pregnancy category C. This means that glibenclamide may harm an unborn baby if used during pregnancy but potential benefit may warrant use of the drug in pregnant woman despite potential risks. Always inform your doctor if you are pregnant or are planning for conception.
Lactating women: It is not known whether glibenclamide passes into breast milk or if it could harm the baby. Do not take glibenclamide with out first talking to doctor if you are breast feeding a baby.
Avoid drinking alcohol. Alcohol decreases blood sugar level and increases the risk hypoglycemia.

Glibenclamide is available in the form of tablet.

Use glibenclamide as directed by your physician, your physician prescribes depending on the severity of disease. Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.

If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses of glibenclamide at the same time to cover up the missed dose.

In case of overdose of glibenclamide contact your nearest poison control centre or emergency medical centre for immediate care by physician.

The overdosge symptoms of glibenclamide include
  • Hypoglycemic symptoms like Low body temperature, dizziness, headache, confusion, blurred vision
  • Severe hypoglycemic symptoms like convulsions, coma

The following are the side effects observed for glibenclamide

  • Nausea, stomach fullness, and heart burn
  • Skin reactions like urticaria
  • Blurred vision

If you experience any of the following side affects stop the glibenclamide medication and consult your doctor immediately

  • Allergic reactions like difficulty breathing, chest congestion, swelling of face, lips
  • Sever hypoglycemic effects like blurred vision, dizziness, and coma   

Store glibenclamide at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.

  •  Proper diet and regular exercise are important to keep control normal blood sugar levels.
  • It is advised to have the blood or urine glucose test to monitor the drug therapy.
  • Symptoms of low blood sugar levels are
    1. Nausea, extreme hunger, rapid heartbeat
    2. Dizziness, drowsiness, headache, restlessness, anxiety, blurred vision
    3. Convulsions, loss of consciousness, coma and low body temp.
  • Symptoms of high blood sugar levels are
    1. Excessive thirst, increased urination, increased hunger,
    2. Headache, confusion, blurred vision, weight loss, fatigue
    3. Viginal and skin infection, slow healing of sores, ulcers and cuts, Erectile dysfunction
It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information.

Written by: Healthplus24 team
Date last updated: May 31, 2012

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