General Information
Brand names and manufacturer
Type: OTC/Prescription/schedule

What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any

Fivoflu (Dabur)
Florac (Cadila(Oncocare))

Fluorouracil is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner.

Fluorouracil is pronounced as: FLURE-oh-UE-ra-sil

Fluorouracil is an anti cancer drug belongs to anti metabolite group of drugs.

Fluorouracil is used in the treatment of various types of cancer.  Topical solution or cream is used to treat superficial basal cell carcinoma.

  • Take fluorouracil exactly as prescribed by your doctor. If you do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
  • Fluorouracil is usually given by injection to vein by your doctor who is specialized in cancer treatment.
  • Fluorouracil vial should be inspected visually for particulate matter prior to administration. Preparations of fluorouracil containing visibly opaque particles should not be used.
  • Wash and dry the affected area before you apply fluorouracil cream or topical solution. Do not apply the medication near the eyes and nose.
  • Do not use the fluorouracil in larger amounts or for longer duration than recommended by your doctor or do not stop taking the medication with out consulting your doctor.
  • Always remember to inform your doctor or pharmacist if you are currently taking any OTC drugs or prescription drugs like
    1. Oral anticoagulants like warfarin
    2. Anti convulsants like phenytoin
    3. Any other anti cancer drugs
  • This may not be the complete list of drugs interact with fluorouracil, ask your pharmacist if any other drugs interact with this medication.
  • Inform your doctor or pharmacist if you have any of the following medical conditions as fluorouracil should be cautiously used.
    1. Liver disease
    2. Kidney disease
    3. Enzyme deficiency Dihydropyrimidine dehydrogenase (DPD)

Old people:
Pregnant woman: Fluorouracil belongs to FDA pregnancy category X. This means that fluorouracil will cause birth defects if used during pregnancy. The use of this drug in pregnancy clearly outweighs any possible benefit. Do not use fluorouracil if you are pregnant or are planning for conception. 

Lactating women: Fluorouracil passes into breast milk and harm nursing baby. Do not use fluorouracil if you are breastfeeding your child.

Fluorouracil is available in the form of injection, tablets and cream.

Use fluorouracil as directed by your physician, your physician prescribes depending on the severity of disease. Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.

If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses of fluorouracil at same time to cover up the missed dose.

In case of overdose of fluorouracil contact your nearest poison control centre or emergency medical centre for immediate care by physician.

The following are the side effects you may experience with fluorouracil

  • Nausea, vomiting and loss of appetite
  • Skin sensitivity, redness on the skin and sun burn may occur.

If you experience any of the following side affects stop the fluorouracil medication and consult your doctor immediately

Allergic reactions like difficult breathing, skin rashes, hives, swelling of face, lips

Store fluorouracil at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.

  • Laboratory tests like complete blood count need to do to monitor the adverse effects of fluorouracil 
  • Fluorouracil lowers the immunity; avoid contact with the people who have cold and infections
  • Avoid direct sun light and UV rays after applying the cream if it is not avoidable use the sunscreen or wear the protective clothing.

It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information.

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Written by: healthplus24 team
Date last updated: May 31, 2012