Domperidone is an anti-emetic that helps relieve the feelings of nausea and vomiting. It also helps move the food quickly through the digestive system, making it easier for one to overcome nausea.
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Domperidone acts as an anti-dopaminergic agent. When dopamine is released by the hypothalamus, it stops release of hormone prolactin from the pituitary gland. Prolactin helps in the stimulation of lactation and lack of it puts an end to the production of breast milk. Domperidone, however, not used in the US for this or any other use. This is because there is a lack of evidence related to the effects and safety of the drug on the infant.
Before taking the drug, read the printed information on the leaflet inside the pack given by the manufacturer. Take the drug as advised by your doctor. Domperidone is available in the form of tablets, orally disintegrating tablets, suppositories and suspension.
Take the tablet half an hour before the meal. You can have Domperidone after a meal, but the drug will take time to have an effect on the symptoms. The dissolvable tablets can be placed on the tongue and allowed to melt, before swallowing.
Domperidone is prescribed for a no more than 7 days.
Domperidone can cause some of the following side-effects:
Patients are advised not to take the medicine, if:
The neurological side effects in children due to Domperidone are very rare. The effect of drugs on newborns is unknown. Thus, it is not recommended to nursing mothers or pregnant women.
The drug is not recommended for patients who are 60 years and above. It can lead to sudden cardiac death due to increase in heart rate.
There is limited data available related to the effects of Domperidone in pregnant women. Thus, use of Domperidone in pregnancy is carried out only when there is justified anticipated therapeutic benefit for the mother.
The drug is excreted in breast milk and its effect on the newborn is not yet clear. Thus, breastfeeding mothers are not recommended Domperidone.
The effects of Domperidone are negligible on the patient’s ability to drive or operate machines.
If you miss a dose, take it as soon as you remember it. If it is time for the next dose, skip the one missed. Never take a double dose.
Call your doctor immediately, if you overdose on the medicine.
What to discuss with the doctor/pharmacist
The drug can interact with itraconazole and ketoconazole. Thus, avoid Domperidone in case you use anti-fungal medications. Avoid the drug is you use macrolide antibiotics. Inform your doctor if you take:
Do not take the medication with grapefruit juice.
Domperidone needs to be swallowed whole with a glass of water. Adults and adolescents need to take 1 to 2 tablets about 3 to 4 times a day before meals. Never take more than 8 tablets within 24 hours.
Children who weigh less than 35 kg should not be given this medicine. Usually, children are given 0.25 to 0.5 mg/kg body weight, 3 to 4 times a day before meals.
Store the tablets in the original package, in a cool and dry place. Keep out of reach of children ALWAYS
Written by: healthplus24.com team
Date last updated: June 08, 2015
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