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General Information
What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any

Regubeat tab(GSK)
Norpace cap (RPG)

Disopyramide is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner.

Disopyramide is pronounced as: dye-soe-PEER-a-mide

Disopyramide is an anti arrhythmic drug.

Disopyramide is used for treating and preventing abnormal cardiac rhythms like Supraventricular and ventricular arrhythmias.

  • Take disopyramide exactly as prescribed by your doctor. If do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
  • Take oral dose of disopyramide with one glass of water at regular intervals to be effective.
  • Do not crush or chew the extended release tablets else large dose of drugs will be released at the same time. Swallow it as whole.
  • Do not take disopyramide in larger amounts or for longer duration than recommended by your doctor. 
  • Do not skip doses or stop taking disopyramide without consulting your doctor. Stopping suddenly may worsen cardiac arrhythmias.
  • Disopyramide is known to interact with wide range of drugs. Always remember to inform your health expert if you are currently taking any OTC or prescription drugs like,
    1. Digoxin
    2. Phenytoin (anticonvulsant)
    3. Antibiotics like erythromycin, sparfloxacin
    4. Other antiarrythmic drugs like Flecainide, procainamide, quinidine
    5. Other antihypertensives like beta blockers, calcium channel blockers etc
  • Inform your doctor if you have following medical diseases , as Disopyramide should be used cautiously in these conditions
    1. Predisposition to Urinary retention due to prostate
    2. Diabetes
    3. Glaucoma
    4. Heart failure
    5. Electrolyte disturbance
    6. Sinus node disease without pacemaker
    7. Liver disease

Do not use disopyramide in following conditions

  1. 2nd or 3rd degree heart block without a pace maker
  2. On Astemizole and Terfenadine medication( antihistamine)
  3. Cisapride
  4. History of QT prolongation


Old people:
Pregnant woman: Disopyramide belongs to FDA pregnancy category C. This means that disopyramide may harm an unborn baby if used during pregnancy but potential benefit may warrant use of the drug in pregnant woman despite potential risks. Always inform your doctor if you are pregnant or are planning for conception.

Lactating women: It is not known whether disopyramide passes into breast milk or if it could harm the baby. Do not take disopyramide with out first talking to doctor if you are breast feeding a baby.
Other: Avoid extreme heat or exercise when on Disopyramide as the risk of heat stroke is more.

Disopyramide is available in the form of tablets and capsules.

Use as directed by your physician, your physician prescribes depending on the severity of disease.Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.

If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose.

In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.

The overdose symptoms of disopyramide are
  • Dryness of mouth & eyes
  • Blurring of vision
  • Urinary retention
  • Loss of consciousness 
  • Very slow Irregular heartbeat
  • Cardiac arrest

Disopyramide may cause following side effects

  • Giddiness
  • Dryness of eyes , mouth
  • Difficulty in passing urine
  • Blurring of vision
  • Fatigue
  • Body pains

Consult your doctor immediately if notice following symptoms.

  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes. Peeling of skin etc
  • Visual disturbances 
  • chest pain
  • shortness of breath
  • Irregular heart rate, sweating, anxiety 
  • Breathing difficulty, cough
  • Loss of consciousness

Store disopyramide at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.

  • Inform your surgeon or dentist regarding Disopyramide prior to any procedure.
  • Disopyramide causes dizziness and blurring of vision. Hence avoid alcohol and activities like operating heavy machinery, driving etc, which requires you to be alert.
  • Visit your doctor regularly for monitoring your blood pressure, pulse rate and heart rhythm when taking disopyramide.
  • Adopt healthy lifestyle changes like regular exercise, healthy diet; quit smoking, alcohol to improve your overall health.

It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information.

Written by: Healthplus24 team
Date last updated: April 04, 2012

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