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General Information
Brand names and manufacturer
Type: OTC/Prescription/schedule

What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any

Cycloxan (Biochem)
Cyphos (Intas)

Cyclophosphamide is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner.


Cyclophosphamide is pronounced as: SYE-kloe-FOS-fa-mide

What is cyclophosphamide?

Cyclophosphamide is an anticancer drug. It stops the multiplying of cancer cells.

Cyclophosphamide is used to treat many types of cancer. If no other medication works cyclophosphamide is used to treat kidney problems in children.

  • Take cyclophosphamide exactly as prescribed by your doctor. If you do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
  • Cyclophosphamide is usually given by injection to vein by your doctor who is specialized in cancer treatment.
  • Cyclophosphamide vial should be inspected visually for particulate matter prior to administration. Preparations of cyclophosphamide containing visibly opaque particles should not be used.
  • It is preferable to take cyclophosphamide tablet on empty stomach if you experience stomach upset you can take it with food. 
  • Do not take the cyclophosphamide in larger amounts or for longer duration than recommended by your doctor or do not stop taking the medication with out consulting your doctor.
  • Always remember to inform your doctor or pharmacist if you are currently taking any OTC drugs or prescription drugs like
    1. Dogoxin
    2. Phenytoin, phenobarbitol
    3. Ketoconazol
  • This may not be the complete list of drugs interact with cyclophosphamide, ask your pharmacist if any other drugs interact with this medication.
  • Inform your doctor or pharmacist if you have any of the following medical conditions as cyclophosphamide should be cautiously used.
    1. Liver disease
    2. Kidney disease
    3. If adrenal gland is removed by surgery.

Do not cyclophosphamide if you are suffering from blood disorder.


Old people:

Pregnant woman: Cyclophosphamide belongs to  FDA pregnancy category D. This means that cyclophosphamide can harm an unborn baby and cause birth defects if used during pregnancy. Do not use cyclophosphamide with out your doctor consent however its use is justified if the benefits to the mother outweigh the risks. Always inform your doctor if you are pregnant or are planning for conception.
Lactating women: Cyclophosphamide passes into breast milk and harm nursing baby. Do not use cyclophosphamide with out the consent from your doctor if you are breastfeeding your child.

Cyclophosphamide is available in the form of tablets and injection.

Use cyclophosphamide as directed by your physician, your physician prescribes depending on the severity of disease.Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.

If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses of cyclophosphamide at same time to cover up the missed dose. 

In case of overdose of cyclophosphamide contact your nearest poison control centre or emergency medical centre for immediate care by physician.

  • Bloody urine
  • Irregular heart beat
  • Yellowing of skin and eyes

The following are the side effects you may experience with cyclophosphamide

  • Nausea, vomiting
  • Stomach pain
  • Changes in skin color and texture

If you experience any of the following side affects stop the cyclophosphamide medication and consult your doctor immediately

  • Allergic reactions like difficult breathing and skin rashes
  • Severe nausea and vomiting
  • Severe kidney problems

Store cyclophosphamide at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.

  • Laboratory tests like complete blood count need to do to monitor the adverse effects of cyclophosphamide
  • Cyclophosphamide lowers the immunity, avoid contact with the people who have cold and infections
 It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information.

Written by: healthplus24 team
Date last Updated: November 16, 2011  

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