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General Information
What should I know before taking this drug
Dosage information
Adverse reactions
Haemoprot vial [Troikaa]
Aprotin inj (VHB (Cardion))
Aprotinin is a prescription medication available from your pharmacy store only with the prescription of a qualified medical practitioner.
Aprotinin is pronounced as: a-proe-TYE-nin
Aprotinin is an anti fibrinolytic drug which inhibits breakdown of blood clots.
Aprotinin is used to prevent and treat excessive blood loss, to minimize bleeding and the need for blood transfusions in open heart surgeries.
  • Test dose of aprotinin should be given before giving the loading dose to look for any possible allergic reaction to the drug.
  • Aprotinin is administered as an intravenous injection.
  • Do not take the medication in larger amounts or for longer duration than recommended by your doctor. 
  • Do not skip doses or stop taking aprotinin without consulting your doctor.
  • Always remember to inform your health expert if you are currently taking any OTC or prescription drugs like,
    1. Aminoglycoside antibiotics like gentamicin, streptomycin
    2. ACE inhibitors like captopril, enalapril
    3. Tretinoin (anti acne drug) 
  • Inform your doctor if you have following medical conditions, as Aprotinin should be used cautiously in these conditions
    1. previous history of heart surgery
    2. Renal disease
    3. history of allergies
Do not use aprotinin if you are hypersensitive to it.

What are the precautions I should follow for aprotinin?

Children: Aprotinin should not be used in children.

Old people:
Pregnant woman: Aprotinin belongs to FDA pregnancy category B. This means that aprotinin is safe during pregnancy and is not expected to cause any harm to the unborn baby. Always inform your doctor if you are pregnant or are planning for conception.
Lactating women: It is not known whether aprotinin passes into breast milk or if it could harm the baby. Do not take aprotinin with out first talking to doctor if you are breast feeding baby.
Aprotinin is available as injection. It should be administered by a healthcare under strict aseptic precaution.
Use as directed by your physician, your physician prescribes depending on the severity of disease.
Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.
If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose.
In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.
Aprotinin may cause following side effects
  • Fever 
  • Nausea & vomiting
  • Constipation 
  • Light headedness
  • Difficulty in urination
Consult your doctor immediately if notice following symptoms.
  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes. Peeling of skin etc
  • Severe headache, giddiness, confusion
  • Loss of consciousness
  • Fast irregular heartbeat
  • Sudden weight gain
  • Oedema of the hands, feet
  • Weakness on one side of the body
  • Wheezing , chest pain
  • Visual and speech disturbances
Store aprotinin at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.
  • Regular monitoring of your complete blood cell counts, clotting test is required when on aprotinin to monitor for possible side effects.
  • Aprotinin can increase the clotting time of heparinised blood. Therefore inform your lab personnel regarding aprotinin medication prior to under going the lab test.
  • Inform your anaesthetist regarding aprotinin medication as it may increase the side effects due to anaesthetic medication.
  • Consult your doctor immediately if you notice any unusual bleeding form in spite of taking medication.           
It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information. 

Written by: Healthplus24 team
Date last Updated: July 15, 2011