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General Information
What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any
DEMOLOX tab® [Wyeth]
OXAMINE tab® [Psycorem]
Amoxapine is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner.
Amoxapine is pronounced as: a-MOX-a-peen
Amoxapine is an Anti depressant / Tricyclic Anti depressant (TCA).
Amoxapine is used in the management of Depression.
  • Take amoxapine exactly as prescribed by your doctor. If do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
  • Take amoxapine at regular intervals as advised by your doctor for it to be effective.
  • Amoxapine may take up to 3-4 wks to show its beneficial effects. However continue to take it as advised.
  • Do not take the medication in larger amounts or for longer duration than recommended by your doctor.
  • Do not skip doses or stop taking amoxapine without consulting your doctor as it may worsen your symptoms.
  • Always remember to inform your health expert if you are currently taking any OTC or prescription drugs like,
    1. Oral anticoagulant like warfarin
    2. Anti histamine like Terfenadine , Astemizole, cimetidine 
    3. Anti convulsants like phenytoin. Phenobarbitone, carbamazepine
    4. Antibiotics like erythromycin, Rifampicin
    5. Anti hypertensive’s or other heart medication
    6. Anti arrhythmic like Propafenone, Flecainide
  • Inform your doctor if you have following medical diseases , as Amoxapine should be used cautiously in these conditions
    1. Alcoholism
    2. History of suicide attempt or thoughts
    3. History or acute myocardial infarction (heart attack)
    4. Glaucoma
    5. Thyroid disorder
    6. Enlargement of Prostate
    7. Seizure disorder
Do not use amoxapine if you are taking any other anti depressants (like MAOI)

What are the precautions I should follow for amoxapine?


Old people: Caution is advised for usage of amoxapine in older people.

Pregnant woman: Amoxapine belongs to FDA pregnancy category C. This means that amoxapine may harm an unborn baby if used during pregnancy but potential benefit may warrant use of the drug in pregnant woman despite potential risks. Always inform your doctor if you are pregnant or are planning for conception.

Lactating women: It is not known whether amoxapine passes into breast milk or if it could harm the baby. Do not take amoxapine with out first talking to doctor if you are breast feeding a baby.
Avoid alcohol and other sedative drugs as it may increase side effects due to amoxapine.
Amoxapine is available in the form of tablets.
Use as directed by your physician, your physician prescribes depending on the severity of disease.
Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.
If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose.
In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.
The overdose symptoms of amoxapine include
  • Rapid, Irregular heart rate
  • Confusion, disorientation
  • Enlarged pupils
  • Convulsions
  • Loss of consciousness
Amoxapine may cause following side effects
  • Decrease in sexual drive or performance
  • Night mares
  • Blurring of vision
  • Drowsiness 
  • Dryness of mouth
  • Giddiness on changing posture
  • Headache 
  • Palpitations
Consult your doctor immediately if notice following symptoms.
  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes. Peeling of skin etc
  • Uncontrolled movements of the hands, legs, tongue, face
  • Tremors, Jerking movements or stiffness
  • Suicidal thoughts, depression
  • Fever, sweating, Muscle stiffness
  • Worsening of agitation, aggressiveness 
  • Severe mental or mood changes
  • Weakness on one side of the body
  • Urinary retention
Store amoxapine at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.
  • Amoxapine increases the risk for suicidal thoughts or actions, worsening of depression, mood and behavioural changes especially in teenagers, young adults < 25 yrs. Care givers and family members should watch the patients closely and consult the doctor immediately if they notice any such symptoms.
  • Amoxapine may cause dizziness when getting up from sitting or lying down position due to postural hypotension. Use precaution while changing posture to avoid falling down.
  • Avoid getting dehydrated or extreme heat as amoxapine may increase the risk of having heat stroke. Take plenty of oral fluids in hot weather and during exercise
  • Amoxapine may rarely cause a group of symptoms called as Neuroleptic Malignant syndrome characterised by difficulty in swallowing, Muscle stiffness, rapid heart rate, visual disturbances, etc, stop the drug immediately and consult your doctor
  • Amoxapine causes giddiness, drowsiness and visual disturbances as side effects. Therefore when affected do not drive, operate heavy machinery or perform unsafe tasks.
  • Inform your doctor and dentist regarding amoxapine medication prior to any planned procedure. 
It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information.
Written by: Healthplus24 team
Date last Updated: July 15, 2011

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