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General Information
What should I know before taking this drug
Dosage information
Adverse reactions
Additional information if any
TRILIN tab® [Triton (Calyx)]
ELIWEL tab® [Sun]
Amitriptyline is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner.
Amitriptyline is pronounced as: am-ee-TRIP-tih-leen
Amitriptyline is an anti depressant / Tricyclic anti depressant (TCA).
Amitriptyline is used in the management of Depression, nocturnal enuresis and to prevent migraine headache.
  • Take amitriptyline exactly as prescribed by your doctor. If do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
  • Take amitriptyline at regular intervals as advised by your doctor for it to be effective.
  • Amitriptyline may take up to 3-4 wks to show its beneficial effects. However continue to take it as advised.
  • Do not take the medication in larger amounts or for longer duration than recommended by your doctor as it may lead to drug- dependence.
  • Do not skip doses or stop taking amitriptyline without consulting your doctor. 
  • Avoid eating grape fruit or drink juice when on amitriptyline.
  • Amitriptyline is known to interact with wide range of drugs. Always remember to inform your health expert if you are currently taking any OTC or prescription drugs like,
    1. Oral anticoagulant like warfarin
    2. Lithium ( mood stabilizer)
    3. Diuretics like furosemide etc
    4. Oral hypoglycaemic drugs like Chlorpropamide
    5. Anti histamine like Terfenadine , Astemizole
    6. Anti convulsants like phenytoin. Phenobarbitone, carbamazepine
    7. Antibiotics like erythromycin, Rifampicin
    8. Anti hypertensive’s or other heart medication
    9. Anti arrhythmic drugs like quindine flecainide, propafenone
  • Inform your doctor if you have following medical diseases , as Amitriptyline should be used cautiously in these conditions
    1. Bipolar disorder
    2. History or acute myocardial infarction (heart attack)
    3. Diabetes mellitus
    4. Glaucoma
    5. Thyroid disorder
    6. Benign hyperplasia of prostate
    7. Seizure disorder
    8. Pheochromocytoma (adrenal gland tumour)
Do not take amitriptyline if you are taking other anti depressants like MAOI.

What are the precautions I should follow for amitriptyline?


Old people: Amitriptyline should be used cautiously in older people as they more prone for side effects like muscle stiffness, involuntary movements etc
Pregnant woman: Amitriptyline belongs to FDA pregnancy category C. This means that amitriptyline may harm an unborn baby if used during pregnancy but potential benefit may warrant use of the drug in pregnant woman despite potential risks. Always inform your doctor if you are pregnant or are planning for conception.
Lactating women: It is not known whether amitriptyline passes into breast milk or if it could harm the baby. Do not take amitriptyline with out first talking to doctor if you are breast feeding a baby.
Avoid alcohol and other sedative drugs as it may increase side effects due to Amitriptyline.
Amitriptyline is available in the form tablets.
Use as directed by your physician, your physician prescribes depending on the severity of disease.
Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.
If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at same time to cover up the missed dose.
In case of overdose contact your nearest poison control centre or emergency medical centre for immediate care by physician.
The overdose symptoms of Amitriptyline include
  • Irregular heart rate
  • Confusion, agitation
  • Blurring of vision
  • Drowsiness 
  • Convulsions
  • Loss of consciousness
Amitriptyline may cause following side effects
  • Decrease in sexual drive or performance
  • Loss of appetite
  • Night mares
  • Blurring of vision
  • Drowsiness 
  • Dryness of mouth
  • Giddiness
Consult your doctor immediately if notice following symptoms.
  • Allergic reaction like swollen lips, hives, difficulty in breathing, rashes. Peeling of skin etc
  • Uncontrolled movements of the hands, legs, tongue, face
  • Tremors, Jerking movements or stiffness
  • Suicidal thoughts, depression
  • Worsening of agitation, aggressiveness 
  • Severe mental or mood changes
  • Weakness on one side of the body
  • Urinary retention
  • Unusual eye movements
Store amitriptyline at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.
  • Amitriptyline may cause dizziness when getting up from sitting or lying down position due to postural hypotension. Use precaution while changing posture to avoid falling down.
  • Avoid getting dehydrated or extreme heat as amitriptyline may increase the risk of having heat stroke. Take plenty of oral fluids in hot weather and during exercise
  • Amitriptyline increases sensitivity to sunlight. Therefore avoid prolong exposure to the sun and wear long sleeved clothing and use sunscreen when you go out in sun.
  • Amitriptyline increases the risk for suicidal thoughts or actions, worsening of depression, mood and behavioural changes especially in teenagers, young adults < 25 yrs. Care givers and family members should watch the patients closely and consult the doctor immediately if they notice any such symptoms.
  • Amitriptyline causes giddiness, drowsiness and visual disturbances as side effects. Therefore when affected do not drive, operate heavy machinery or perform unsafe tasks.
  • If you are a diabetic on amitriptyline medication keep a close watch on blood sugar levels.
  • Inform your doctor and dentist regarding amitriptyline medication prior to any planned procedure. 
It is imp to read manufacturing packaging instruction carefully if available and always do not hesitate to consult pharmacist or physician for any information. 

Written by: Healthplus24 team
Date last Updated: July 15, 2011

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