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Pronunciation:  Ab-SIX-i-mab

What is it

Abciximab is a platelet aggregation inhibitor that blocks platelets from sticking together and forming blood clots. It is the Fab fragment of the chimeric human-murine monoclonal antibody 7E3. The drug binds to the glycoprotein  (GP) IIb/IIIa receptor of human platelets. Thus, inhibiting aggregation, that is, clotting.

Brand names with manufacturer



It is a prescription drug.



Abciximab is used to reduce the chances of heart attack in patients who are required to undergo percutaneous coronary intervention (PCI). This is a procedure where the blocked arteries of the heart are opened. During the procedure to open the blocked arteries, formation of blood clots can occur. These blood clots can block a blood vessel in the heart, leading to a heart attack. Abciximab can help reduce the occurrence of these blood clots by prevention of clumping of the platelets. Other drugs used along with abciximab to prevent the clotting of blood include aspirin and heparin.

What should I know before taking this drug

How to take it

Abciximab is given in the form of an injection at a hospital or doctor’s clinic.

Adverse reactions/side effects

The common side effects of abciximab include:

  • Back pain
  • Dizziness
  • Headache
  • Nausea
  • Pain at injection site
  • Stomach pain
  • Vomiting

Severe side effects include:

  • Severe allergic reaction like rash, hives, difficulty breathing, swelling of the mouth, face, lips, tongue
  • Chest pains
  • Fainting
  • Fever and chills
  • Severe or persistent dizziness
  • Headache
  • Slow heartbeat
  • Swelling of the hands, ankles, or feet
  • Increased menstrual bleeding
  • Pain, redness or swelling at the injection site
  • When not to take the medicine

Do not take the medicine if:

  • You are allergic to murine proteins or any other ingredient in Abciximab
  • Patients who have had a stroke within the past 2 years
  • Patients with an aneurysm, brain cancer, problems with blood vessels in the brain
  • Suffer from active internal bleeding, low blood platelet count or clotting problems
  • Patients who are receiving or are going to receive dextran injection
  • Patients who were given or are still receiving anticoagulant since the last 7 days
  • Patients who have undergone a major surgery/trauma or suffering from clotting problems


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Abciximab is NOT recommended for use in children.

Geriatric Use

Studies have found no difference in the safety or efficacy of the drug in patients aged 65 to less than 75 as compared to younger patients.

Pregnant women

Abciximab comes under Pregnancy Category C. There is no information whether Abciximab can cause fetal harm when given to pregnant women. Thus, it should be given in pregnancy only when the potential benefits outweigh potential risks.

Lactating women

There is no proof if abciximab is excreted in human milk. Thus, one should exercise caution when giving the drug to a nursing woman.

What should I do if

  • I miss dose(s): If you miss a dose, contact your doctor immediately.
  • I take an overdose: If you overdose, call your doctor or the emergency department immediately.

What to discuss with the doctor/pharmacist

Drug interactions

There are drugs that can interact with abciximab. Inform your doctor if you are on anticoagulants (warfarin and heparin), dipyridamole, NSAIDs (ibuprofen), ticlopidine, or thrombolytics.

The drug may interact with other medications as well. Thus, discuss all the medications and supplements you are currently using with your doctor.

Dosage form


Each dose varies from patient to patient. Thus, follow the dose advised by the doctor. For the injectable form adults are given 250 micrograms (MCG) per kg of body weight injected 10 to 60 minutes before the procedure. The maintenance dose is given at 0.125 mcg/kg of body weight per minute (maximum of 10 mcg/minute) by IV for 12 hours.

Patients with unstable angina will require 250 mcg/kg of body weight injected. The maintenance dose is given at10 mcg/minute by IV for 18 to 24 hours, that ends 1 hour after the procedure is complete.


Only a healthcare provider can handle and store abciximab. Keep the drug away from the reach of children and pets.

Written by: team

Date last updated: June 08, 2015

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