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Metabolic Syndrome 

Introduction to Metabolic Symdrome

Metabolic syndrome is a group of conditions including metabolic and nonmetabolic disorders, which are related to defects in insulin sensitivity, risk of developing type 2 diabetes and cardiovascular diseases. People suffering with this syndrome show resistance to insulin and hence it is called as insulin resistance syndrome or metabolic syndrome X or Reaven’s syndrome.1–3Apart from insulin resistance, the other components of metabolic syndrome includes, hypertension, dyslipidemia, abdominal obesity, hyperuricemia and hyperleptinemia.

It was Reaven who first described metabolic syndrome X as a cluster of diabetes, hypertension and coronary artery disease with dyslipidemia in 1988.4
It will be very helpful if the disease is recognized at early stages to have an optimistic impact and decrease long-term morbidity.

Occurence of Metabolic Syndrome in Different Groups

A large proportion of people have being affected with the abnormalities of metabolic syndrome. Studies have shown that more than 70% of adults have at least one major characteristic of the metabolic syndrome.5

The prevalence of metabolic syndrome varies among countries. Studies among population suggest an age-standardized prevalence of this syndrome and are 15.7% in men and 14.2% in women.6 Data from studies indicate that high prevalence is due to increasing obesity and inactive lifestyles. Some changes in lifestyle like low fat diet and exercises would be beneficial in reducing the prevalence of metabolic syndrome.7

Symptoms of Metabolic Symdrome

Symptoms of metabolic syndrome

Metabolic syndrome involves several disorders and symptoms include the              

Risk Factors for Metabolic Symdrome

Risk factors for metabolic syndrome

Since metabolic syndrome is a multiple disorder, it includes a number of risk factors        

Management of Metabolic Symdrome

Management of metabolic syndrome

Metabolic syndrome can be managed through prevention and identification of the major risk factors like type 2 diabetes, cardiovascular disease, atherogenic dyslipidemia and hypertension. Lifestyle therapies or changes


Written by: Healthplus24 team
Date last updated: August 16, 2011

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References 

 

  1. Reaven G. Insulin resistance, compensatory hyperinsulinemia and coronary heart disease: Syndrome X revisited. In: Jefferson LS, Cherrington AD (eds). Handbook of Physiology: The Endocrine Pancreas and Regulation of Metabolism. Vol. 2, Sect. 7, New York: Oxford University Press, 2001.
  2. Haffner SM, Valdez RA, Hazuda HP, et al. Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes. 1992; 41: 715–227.
  3. Laaksonen DE, Lakka HM, Niskanen LK, et al. Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol. 2002; 156: 1070–1077.
  4. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988; 37: 1595–1607.
  5. Ferrannini E, Natali A. Essential hypertension, metabolic disorders, and insulin resistance. Am Heart J. 1991; 121: 1274–1282.
  6. Hu G, Qiao Q, Tuomilehto J, et al., DECODE Study Group. Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in non-diabetic European men and women. Arch Intern Med.2004; 164: 1066–1076.
  7. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA.2001; 285: 2486–2497.
  8. Caprio SK. Can we agree on a definition of the metabolic syndrome in children?. PAS/ASPN/IPHA/LWPES Topic Symposium: Consequences of Metabolic Syndrome in Children: Hypertension, Diabetes and Renal Disease. Program and abstracts of the Pediatrics Academic Societies Annual Meeting; May 14–17, 2005; Washington, DC.
  9. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Executive summary of the third report of the National Cholesterol Education 11.
  10. Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001; 285: 2486–2497.
  11. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002; 106: 3143–3421.
  12. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA. Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary. Circulation. 2005; 112: e285–e290.
  13. Grundy SM, Cleeman JI, Donato KA, Eckel RH, Franklin BA. Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005; 112: 2735–2752.
  14. Alberti KGMM, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group. The metabolic syndrome—A new worldwide definition. Lancet. 2005; 366: 1059–1062.
  15. Wyatt HR, Wing RR, Hill JO. The National Weight Control Registry. In: Bessesen DH, Kushner RF (eds). Evaluation and Management of Obesity. Philadelphia, PA: Hanley & Belfus Inc. 2002, pp. 119–124.
  16. Wing RR, Jeffery RW. Food provision as a strategy to promote weight loss. Obes Res. 2001; 9(Suppl 4): 271S–275S.
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