Paget’s disease, also known as osteitis deformans is considered as the next most common bone disorder to osteoporosis and is commonly noticed in England, USA, Australia and New Zealand and rarely in Scandinavia, Asia and Africa. Paget’s disease is characterized by excessive bone destruction in certain specific areas of the bone, which is followed by new bone formation. Eventually the normal bone marrow is replaced by another type of tissue that is incapable of performing normal functions of the bone marrow. Paget’s disease is noticed more commonly in individuals above the age of 50 years and affects both men and women. It is rarely noticed in individuals younger than 40 years of age. Although asymptomatic most of the times, Paget’s disease is characterized by bone pain and deformity in the bones.^{1, 2} 

Causes of Paget's Disease of Bone

Causes of pagets disease of bone

The exact cause of Paget’s disease has not yet been confirmed, while viral infection and genetic factors have been known to play a vital role in the occurrence of the disease. Other factors that may have a role in the incidence of   

 
Risk Factors for Paget's Disease of Bone

Family history of Paget’s disease, over 50 years of age, low dietary intake of calcium and chronic exposure to industrial toxins may be considered as the possible risk factors.

Signs and Symptoms of Paget's Disease of Bone

Signs and symptoms of pagests disease of bone

Paget’s disease is often asymptomatic and is identified incidentally in individuals who are undergoing certain routine tests such as radiography. In others it may result in bone pain, bone deformity or fracture and also lead to other   
 
Diagnosis of Paget's Disease of Bone

Diagnosis of pagests disease of bone

The diagnosis of Paget’s disease is most often based on the routine laboratory investigations and radiographs for other disorders. In case of individuals who are symptomatic, the diagnosis is based on the signs and symptoms
 
Treatment of Paget's Disease of Bone

Treatment of pagets disease of bone

Paget’s disease cannot be cured. However, the amount and severity of bone destruction can be effectively minimized with use of certain specific medications. The medications that belong to the group of bisphosphonates are helpful 
 
Alternative Therapy of Paget's Disease of Bone

No alternative therapeutic modalities are helpful in Paget’s disease. Mild exercises may be advised in certain cases but a doctor’s advice should always be taken before initiation of any type of exercise as it may lead to fracture of the weakened bones.

Prevention of Paget's Disease of Bone

Paget’s disease cannot be prevented though the severity of the disease and its progression can be prevented with early diagnosis and prompt treatment.

Complications of Paget's Disease of Bone

The possible complications of Paget’s disease include bone deformity or fracture of the affected bones, heart failure (in severe cases), increased concentration of calcium, deafness and loosening of the teeth due to microfracture of the bone that supports the teeth.

Living with Paget’s Disease

Paget’s disease is a long-term disorder that may be asymptomatic for a prolonged duration. Prompt treatment can result in decrease in the rate of bone destruction. However, periodic visit to the doctor is necessary to monitor the progression of the condition.⁴       

Written by: Healthplus24 team
Date last updated: August 15, 2011