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Amifostine
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General Information
Brand names and manufacturer
Type: OTC/Prescription/schedule
Pronunciation 

Uses
 
What should I know before taking this drug
 
Precautions
 
Dosage information
  
Adverse reactions
 
Storage
 
Additional information if any
 
 
 
Amiphos (Dabur)
Cytofos (Sun(Inca))
Ethyol
 
Amifostine is a prescription drug available from your pharmacy store only with the prescription of a qualified medical practitioner.
 
Amifostine is pronounced as: A-mi-FOS-teen
 
Amifostine is a anti cancer drug
 
Amifostine is used to reduce renal problems while treating with anti cancer drug cisplantin.
Amifostine is also used to reduce the dry mouth in head and neck radiation therapy.
 
How to use amifostine
Take amifostine exactly as prescribed by your doctor. If you do not understand these instructions ask your pharmacist, nurse or doctor to explain them to you.
 
Amifostine is usually given by injection by IV by your doctor.
 
Amifostine should be inspected visually for particulate matter prior to administration. Preparations of amifostine containing visibly opaque particles should not be used.
 
Always remember to inform your doctor or pharmacist if you are currently taking any OTC drugs or prescription drugs like
  • Beta blockers like atenolol, propranolol
  • ACE inhibitors like enalapril
  • Any antihistamines
This may not be the complete list of drugs interact with amifostine, ask your pharmacist if any other drugs interact with this medication.
 
Inform your doctor or pharmacist if you have any of the following medical conditions as amifostine should be cautiously used.
  • Heart problems like Low BP or High BP, irregular heart beat
  • Kidney problems
Do not amifostine if you have low or high blood pressure.
 

What are the precautions I should follow for amifostine?

Children: 

Old people:

Pregnant woman: Amifostine belongs to FDA pregnancy category C. This means that amifostine may harm an unborn baby if used during pregnancy but potential benefit may warrant use of the drug in pregnant woman despite potential risks. Always inform your doctor if you are pregnant or are planning for conception.

 
Lactating women: It is not known whether amifostine passes into breast milk or if it could harm the baby. Do not take amifostine with out first talking to doctor if you are breast feeding a baby.
 
Other:
Drink plenty of fluids to avoid low blood pressure while taking amifostine
 
Amifostine is available in the form of injection.
 
Use amifostine as directed by your physician, your physician prescribes depending on the severity of disease.
 
Use the complete course of medication as prescribed by your physician even though you feel better after one or two days of usage of medication.
 
If it is almost the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses of amifostine at same time to cover up the missed dose.
 
In case of overdose of amifostine contact your nearest poison control centre or emergency medical centre for immediate care by physician.
The main over dosage symptom of amifostine is hypotension
 
The following are the side effects you may experience with amifostine
  • Dizziness
This is not the complete list of side effects if you notice any other side effects consult your doctor or pharmacist.
 
If you experience any of the following side affects stop the amifostine medication and consult your doctor immediately
  • Sever Dizziness
  • Irregular heart beat
  • Convulsions
Store amifostine at room temp (15 – 30 degrees C). Avoid excessive heat, moisture or direct sunlight, never store in the bathroom.
Keep it out of reach of children. Make sure that any leftover portion is disposed off safely.
 
  • Amifostine can cause dizziness. Avoid the driving or operating the machinery.
  • Avoid taking alcohol while taking amifostine.
  • If you have vomiting discuss with your doctor so that you will not be dehydrated.

Written by: healthplus24
Date last modified: july 8, 2011

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Disclaimer : Every effort has been made to ensure that the information provided by healthplus24 team is accurate, up to date and complete but no guarantee is made to that effect. The information contained herein is intended to supplement not substitute for the expertise and knowledge of health care professional. The information is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, adverse effects etc. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Healthplus24 team disclaims any liability for the decisions you make based on this information.

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  Pregnancy Categories  
 
Category A
Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).

Category B
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Category D
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Category X
Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
 

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