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Symptoms of Anemia

Symptoms of anemia vary depending on the severity of the condition. Symptoms can sometimes be vague and be detected only during a clinical examination and investigation.

In general, the symptoms and signs of anemia may include the following:

  • Generalized weakness and fatigue
  • Shortness of breath (dyspnea) on exertion
  • Dizziness
  • Poor concentration
  • Ringing in the ears (tinnitus)
  • Irritability and other mood disturbances
  • Mental confusion
  • Loss of sexual drive
  • Pale skin and mucosal linings
  • Koilonychia (flattened and brittle nails)
  • Enlarged spleen

Pica, defined as the craving or compulsive ingestion of non-food substances such as earth, clay, chalk, wax, soap and grass may be a symptom of iron deficiency anemia, although it may also occur in those who have normal levels of hemoglobin.1

Iron deficiency had also been shown to contribute to the pathophysiology of attention-deficit hyperactivity disorder (ADHD) in children.2 Chronic anemia may result in behavioral disturbances and reduced academic performance in children of school-going age.

Anemia, which is severe will trigger a compensatory mechanism in the body which responds by increasing the cardiac output, leading to heart failure. The incidence of anemia in patients with heart failure is as high as 50%. Although the causes are multifactorial, inflammation appears to be the primary cause of anemia in heart failure, along with effects from increased plasma volume, effects of drug therapy and other complications of heart disease.3   

Next page: Diagnosis of Anemia

Written by: Healthplus24 team
Date last updated: January 05, 2010

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References 
  1. Louw VJ, du Preez P, Malan A, et al. Pica and food craving in adult patients with iron deficiency in Bloemfontein, South Africa. S Afr Med J. 2007; 97(11): 1069–1071.
  2. Konofal E, Lecendreux M, Arnulf I, Mouren MC. Iron deficiency in children with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2004; 158(12): 1113–1115.
  3. Handelman GJ, Levin NW. Iron and anemia in human biology: A review of mechanisms. Heart Fail Rev. 2008 Mar 25; (Epub ahead of print).
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